Peer-reviewed Publications
Liang, W., Diao, R.Y., Quiles, J.M., Najor, R.H., Woodall, B.P., Leon, L.J., Duran, J., Cauvi, DM, De Maio, A., Adler, E.D., and Gustafsson Å.B., The Small GTPase Rab7 Regulates Release of Mitochondria in Extracellular Vesicles in Response to Lysosomal Dysfunction. Preprint on BioRxiv (https://doi.org/10.1101/2023.02.11.528148)
Quiles, J.M., Najor, R.H., Gonzalez, E. Jeung, M. Liang, W. Burbach, S.M., Zumaya, E.A., Diao, R.Y., Lampert, M.A., and Gustafsson Å.B., Deciphering Functional Roles and Interplay Between Beclin 1 and Beclin 2 in Autophagosome Formation and Mitophagy. Science Signaling, Jan 31, 16 (770):eabo4457, 2023. https://www.science.org/stoken/author-tokens/ST-1000/full
Moyzis, A.G., Lally, N.S., Liang, W., Najor, R.H., Orogo, R.H., and Gustafsson, Å.B., Mcl-1 Differentially Regulates Autophagy in Response to Changes in Energy Status and Mitochondrial Damage. Cells, 11(9), 1469, 2022. https://doi.org/10.3390/cells11091469.
Quiles, J.M., and Gustafsson Å.B., The role of mitochondrial fission in cardiovascular health and disease. Nature Rev Cardiol. May 6, 2022. doi: 10.1038/s41569-022-00703-y
Zhu S, Chen Z, Zhu M, Shen Y, Leon LJ, Chi L, Spinozzi S, Tan C, Gu Y, Nguyen A, Zhou Y, Feng W, Vaz FM, Wang X, Gustafsson, Å.B., Evans SM, Kunfu O, Fang X. Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy. Circ Heart Failure 2021, 14(6):e008289, 2021
Moyzis AG, Lally NS, Liang W, Leon LJ, Najor RH, Orogo AM, Gustafsson ÅB. Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise. J Mol Cell Cardiol. 2020; S0022-2828(20)30231-5. doi:10.1016/j.yjmcc.2020.07.009 [Link]
Liang W, Moyzis AG, Lampert MA, Diao RY, Najor RH, Gustafsson ÅB. Aging is associated with a decline in Atg9b-mediated autophagosome formation and appearance of enlarged mitochondria in the heart. Aging Cell. 2020; e13187. doi:10.1111/acel.13187 [Link]
Shires, S. E., Quiles, J. M., Najor, R. H., Leon, L. J., Cortez, M. Q., Lampert, M. A., Mark, A., & Gustafsson, Å. B., Nuclear Parkin Activates the ERRα Transcriptional Program and Drives Widespread Changes in Gene Expression Following Hypoxia. Scientific reports, 10(1), 8499. 2020. doi:10.1038/s41598-020-65438-7 [Link]
Woodall, B.P., Orogo, A.M., Najor, R.H., Cortez, M.Q., Moreno, E.R., Wang, H., Divakaruni, A.S., Murphy, A.N., Gustafsson, Å.B., Parkin Does Not Prevent Accelerated Cardiac Aging in Mitochondrial DNA Mutator Mice. JCI Insight. 4(10):e127713, 2019. [Link]
Lampert, M.A., Orogo, A.M., Najor, R.H., Hammerling, B.C., Leon, L.J., Wang, B.J., Kim, T., Sussman, M.A., Gustafsson Å.B. Nix and Fundc1-Mediated Programmed Mitophagy is Required for Mitochondrial Network Remodeling during Cardiac Progenitor Cell Differentiation. Autophagy 2019 Feb 11. doi: 10.1080/15548627.2019.1580095. [Link]
Korski, K.I., Kubli, D.A., Wang, B.J., Khalafalla, F.G., Monsanto,. M.M., Firouzi, F., Echeagaray, O.H., Kim T., Adamson, R.M., Dembitsky, W.P., Gustafsson Å.B., and Sussman, M.A. Hypoxia Prevents Mitochondrial Dysfunction and Senescence in Human c-Kit+ Cardiac Progenitor Cells. Stem Cells 2019 Jan 10. doi: 10.1002/stem.2970. [Link]
Moyzis, A.G., and Gustafsson, Å.B. Multiple recycling routes: Canonical vs. non-canonical mitophagy in the heart. Biochim Biophys Acta Mol Basis Dis. 1865(4):797-809, 2019. [Link]
Gustafsson, Å.B. and Dorn, G.W. II., Evolving and expanding the roles of mitophagy as a homeostatic and pathogenic process. Physiological Reviews. 99(1): 853-892, 2019. [Link]
Woodall, B.P, and Gustafsson Å.B. Autophagy – A Key Pathway for Cardiac Health and Longevity. Acta Physiol (Oxf). 223(4): e13074, 2018. [Link]
Lampert M.A., and Gustafsson Å.B. Balancing Autophagy for a Healthy Heart. Curr Opin Physiol. 1:21-26, 2018. [Link]
Castaldi, A., Dodia, R.M., Orogo, A.M., Zambrano, C.M., Najor, R.H., Gustafsson, Å.B., Heller Brown, J., Purcell, N.H.. Decline in cellular function of aged mouse c-kit+ cardiac progenitor cells. J Physiol. 595(19):6249-6262, 2017. [Link]
Hammerling, B.C., Shires, S.E., Leon, L.J., Cortez, M.Q., and Gustafsson, Å.B. Isolation of Rab5-positive endosomes reveals a new mitochondrial degradation pathway utilized by BNIP3 and Parkin. Small GTPases. Jul:11: 1-8, 2017. [Link]
Hammerling, B.C., Najor, R.H., Cortez, M.Q., Shires, S.E., Leon, L.J., Gonzalez, E.R., Boassa, D., Phan, S., Thor, A., Jimenez, R.E., Li,. H., Kitsis, R.N., Dorn G.W. 2nd., Sadoshima, J., Ellisman, M.H., Gustafsson, Å.B., A Rab5 Endosomal Pathway Mediates Parkin-Dependent Mitochondrial Clearance. Nat. Comm. 8:14050, 2017. PMCID:PMC5290275 [Link]
Shires S.E., Kitsis R.N., and Gustafsson Å.B. Beyond Mitophagy: The Diversity and Complexity of Parkin Function. Circ Res. 120(8):1234-1236, 2017 [Link]
Leon, L.J., and Gustafsson, Å.B., J Mol Cell Cardiol. Staying Young at Heart: autophagy and adaptation to aging J Mol Cell Cardiol. (95):78-82, 2016. [Link]
Zhong, Z., Umemura, A., Sanchez-Lopez, A., Liang, S., Shalapour, S., Wong, J., Boassa, D., Perkins, G., He, F., Ellisman, M.H., Seki, E., Gustafsson, Å.B., Diaz-Meco, M.T., Moscat, J., Karin, M. p62/SQSTM1-dependent Mitophagy Prevents Excessive Inflammation by Attenuating NLRP3 Inflammasome Activation. Cell. 164(5): 896-910, 2016. [Link]
Shirakabe, A, Fritzky, L, Saito, T, Zhai, P, Miyamoto, S, Gustafsson, ÅB, Kitsis, RN, and Sadoshima, J. Evaluating mitochondrial autophagy in the mouse heart. J Mol Cell Cardiol. [Link]
Orogo, A.M., Gonzalez, E.R., Kubli, D.A., Baptosta, I.L., Ong, S.B., Prolla, T.A., Murphy, A.N., and Gustafsson, Å.B. Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival. J Biol Chem 290(36), 22061-75, 2015. [Link]
Kubli, D.A., Moyzis, A.G., Hanna, R.A., Lee Y., and Gustafsson, Å.B. PINK1 is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes. PLOS One 10(6): e0130707, 2015. PMCID:PMC4482400 [Link]
Song M., Gong G., Burelle Y., Gustafsson Å.B., Kitsis R.N., Matkovich S.J., Dorn G.W. 2nd. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circ Res. 117(4):346-51, 2015. [Link]
Lee, Y., Kubli, D.A., Hanna, R.A., Cortez, M.N., Lee, H.Y., Miyamoto, S., and Gustafsson, Å.B., Cellular Redox Status Determines Sensitivity to BNIP3-Mediated Cell Death in Cardiac Myocytes. Am J Physiology: Cell Physiol.308: C983-C992, 2015. [Link]
Samse K, Emathinger J, Hariharan N, Quijada P, Ilves K, Völkers M, Ormachea L, De La Torre A, Orogo A.M., Alvarez R, Din S, Mohsin S, Monsanto M, Fischer K.M., Dembitsky W.P., Gustafsson Å.B., and Sussman M.A. Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells. J Biol Chem. 290(22):13935-47, 2015. [Link]
Taylor, A.E., Chesini, G.P., Barlow, M.S., Zhang, X., Gustafsson, Å.B., and Purcell, N.H., Physiological Activation of Akt by PHLPP1 Deletion Protects Against Pathological Hypertrophy. Cardiovasc Res. 105(2): 160-70 [Link]
Din, S., Konstantin, M.H., Johnson, B., De La Torre, A. Voelkers, M. Emathinger J., Toko, H., Collines, B., Ormachea, L., Samse, K., Kubli, D.A. Kraft, A.S., Gustafsson, Å.B., Kelly, D.P., and Sussman, M.A. Metabolic Dysfunction Consistent With Premature Aging Results From Deletion of Pim Kinases. Circ Res. 115(3):766-87, 2014 [Link]
Hammerling, B and Gustafsson, Å.B. Mitochondrial Quality Control in the Myocardium: Cooperation between protein degradation and mitophagy. J Mol Cell Cardiol. 75:122-130, 2014. PMCID:PMC4159946 [Link]
Thomas, R.L., Roberts, D.J., Kubli, D.A., Lee, Y., Quinsay, M.N., Owens, J.B., Fischer, K.M., Sussman, M.A., Miyamoto, S., Gustafsson, Å.B., Loss of MCL-1 Leads to Impaired Autophagy and Rapid Development of Heart Failure. Genes & Dev. 27(12):1365-1377, 2013 (Cover image) [Link]
Kubli, D.A., Quinsay M.N., Gustafsson, Å.B. Parkin Deficiency Results in Accumulation of Abnormal Mitochondria in Aging Myocytes. Communicative & Integrative Biology 6(4), e24511-2, 2013 [Link]
Kubli, D.A., Zhang X, Lee Y, Hanna R.A., Quinsay M.N., Nguyen C.K., Jimenez R, Petrosyan S, Murphy A.N., Gustafsson, Å.B. Parkin Deficiency Exacerbates Cardiac Injury and Reduces Survival Following Myocardial Infarction. J Biol Chem. 288(2): 915-26, 2013. (Selected as JBC’s Paper of the Week & Cover image) [Link]
Gustafsson Lab 